Columbia’s Ph.D. in Chemistry offers a collaborative research environment with access to advanced instrumentation and interdisciplinary labs. These dissertation topics support high-impact work in molecular chemistry, quantum theory, biochemistry, and green technology.
Design of Chiral Catalysts for Asymmetric Hydrogenation Reactions
Mechanistic Insights into Enzyme-Mediated Radical Reactions
Photocatalytic CO₂ Reduction Using Metal–Organic Frameworks
Supramolecular Chemistry for Drug Delivery Systems
Computational Modeling of Reaction Pathways in Biocatalysis
Real-Time NMR Tracking of Protein-Ligand Binding Dynamics
Synthesis of Biomimetic Polymers with Self-Healing Properties
Quantum Mechanical Study of Electron Transfer in Redox Enzymes
Chemical Sensors for Heavy Metal Detection in Water Systems
Single-Molecule Spectroscopy of DNA Base-Pairing Dynamics
Synthetic Route Optimization Using AI-Guided Predictive Models
Transition Metal-Free Coupling Reactions in Green Chemistry
Hybrid Nanomaterials for Targeted Cancer Therapy
Reactive Oxygen Species Scavengers in Neurodegenerative Disorders
Peptoid-Based Scaffolds for Biomolecular Recognition
Electrocatalysis of Water Splitting Using Non-Noble Metal Oxides
Exploring Chemoselectivity in Cascade Organic Reactions
Computational Drug Design Targeting SARS-CoV-2 Main Protease
Mechanistic Studies of Organophosphorus Flame Retardants
3D Printing of Functional Polymers with Responsive Chemistry
Metal Ion Sensing Using Fluorescent Chemosensors
Polymer Electrolyte Design for Next-Generation Batteries
Directed Evolution Approaches in Synthetic Enzymology
Quantum Chemical Descriptors for Predicting Reaction Barriers
Molecular Dynamics Simulations of Membrane Protein Folding
Self-Assembly of Amphiphilic Molecules in Aqueous Media
Photoredox Catalysis in Aqueous and Flow Systems
In Situ Spectroelectrochemistry for Catalytic Mechanism Discovery
Surface Chemistry Modifications for Antifouling Coatings
Exploring Organocatalytic Alternatives to Palladium Cross-Coupling
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