The MD-PhD program by MIT and Harvard Medical School trains physician-scientists to lead breakthroughs in clinical and translational research. These project ideas span molecular diagnostics, AI-enabled health, immunology, synthetic biology, and regenerative medicine.
Targeted Gene Editing for Monogenic Blood Disorders
Neural Decoding Using Electrocorticographic Signals for BCI
Tumor Microenvironment Profiling via Spatial Transcriptomics
Immune Checkpoint Pathway Modulation in Autoimmune Disease
Machine Learning Models for Early Detection of Sepsis
Organoid-Based Drug Screening for Rare Neurological Disorders
Synthetic mRNA Vaccines for Emerging Viral Pathogens
CRISPR Interference Systems for Gene Silencing in Cancer Cells
Integrative Multi-Omics in Personalized Oncology
Wearable Biosensors for Continuous Cardiovascular Monitoring
Engineering CAR-T Cells with Enhanced Tumor Homing
Deciphering Host-Microbiome Interactions in Inflammatory Bowel Disease
Clinical Trial Optimization Using Predictive Analytics
Single-Cell Immune Profiling in Long COVID Patients
Translational Biomarkers for ALS Progression
Bioresorbable Implants for Localized Drug Delivery
High-Resolution fMRI for Functional Brain Mapping in Epilepsy
Systems Pharmacology Models for Polypharmacy Risk Prediction
Nanoparticle-Mediated Targeted Chemotherapy in Pediatric Oncology
Data-Driven Decision Support Systems for ICU Management
Metabolic Reprogramming in Aging-Related Neurodegeneration
Gene Therapy Vector Engineering for CNS Delivery
Digital Twin Models for Personalized Diabetes Management
Mechanobiology of Cancer Cell Invasion and Metastasis
Closed-Loop Neural Interfaces for Neuroprosthetic Rehabilitation
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