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Biological Sciences Research Ideas for MIT PhD Students

Investigate the molecular logic of life and advance biomedical discovery through pioneering research in genetics, systems biology, and cell engineering.

🧬 Introduction

The PhD in Biology at MIT enables students to explore life from molecules to systems. These project ideas reflect the frontiers of biotechnology, neurobiology, and biomedical innovation — driving discoveries in health, evolution, and synthetic design.

💡 Project Ideas

Single-Cell Transcriptomics in Brain Development Studies

CRISPR-Based Genetic Screens for Tumor Suppressor Genes

Synthetic Biology Circuits for Targeted Cancer Therapies

Organoid Models for Studying Human Gut Microbiome Interactions

Machine Learning in Predicting Gene Regulatory Networks

Design of Biosensors for Real-Time Cellular Metabolism Monitoring

Protein Engineering for Enhanced Enzyme Specificity

Epigenetic Regulation in Stem Cell Reprogramming

Spatial Transcriptomics of Developing Embryos

Mechanobiology of Tumor Microenvironment

RNA-Seq Analysis of Neurodegenerative Disease Pathways

Comparative Genomics of Antibiotic-Resistant Bacteria

Light-Controlled Gene Expression Using Optogenetics

Imaging Mitochondrial Dynamics in Live Cells

Targeting DNA Repair Pathways for Chemotherapy Resistance

Evolutionary Systems Biology of Microbial Populations

Integrative Multi-Omics Analysis for Metabolic Disorders

Design of Cell-Free Synthetic Biology Platforms

Neuronal Circuit Mapping in Model Organisms

Bioinformatics Pipeline for Human Microbiome Classification

High-Throughput Screening for Plant Growth Regulators

Real-Time Calcium Imaging in Neuronal Activity

Design of Peptide-Based Therapeutics for Viral Infections

Stochastic Modeling of Intracellular Molecular Interactions

Structural Analysis of Membrane Proteins Using Cryo-EM

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From gene editing to live-cell imaging — our biology experts at Collexa assist with PhD research design, datasets, simulation, and publication.

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